Smrithi Khatri
Ram-Eesh Institute of Vocational and Technical Education, India
Title: Floating capsules of Acyclovir with Piperine as a bioenhancer
Biography
Biography: Smrithi Khatri
Abstract
The aim of the present study was to formulate and characterize the capsules of acyclovir microspheres with piperine which were prepared by emulsification solvent evaporation method. Piperine was added to determine its effect on acyclovir bioavailability. The microspheres were characterized for size, shape, entrapment efficiency, in vitro drug release, and in vivo pharmacokinetic parameters. The morphological characterization of microspheres was done using a scanning electron microscope. The microspheres were spherical and had particle size in the range of 400 to 525 μm. The percent drug entrapment efficiency varied between 56.12 ± 1.32 % to 87.32 ± 5.28 %. The drug release was decreased at higher polymer concentrations. Based on invitro results, further invivo studies were carried out on Sprague Dawley strain rats to evaluate the bioavailability of acyclovir. Nearly two times higher AUC0–24 value of acyclovir-loaded piperine containing microspheres (15614.13 ± 6953.13 ng h ml−1) was observed as compared to the drug solution (7552.33 ± 3219.09 ng h ml−1).